Testing with UFCs

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Myth: UFC’s are the Gold Standard for Cushing’s testing

Fact: UFC stands for Urinary Free Cortisol. In layman's terms this test assesses cortisol by collecting urine for 24 hours. It was once thought that this was the gold standard and the end all and be all in terms of assessing Cushing's in a patient. What we now know is that this is not necessarily true.

Though this test is helpful in assessing for Cushing's in some patients, not all patients have positive labs with this test, even if they DO, in fact, have Cushing's. There are various theories as to why. Cyclical Cushing's patients also tend to report having a lower prevalence of positive UFCs in their test batteries.

Cushing's experts understand that the most effective way to test for Cushing's, especially in cases where it is suspected that the patient is cycling, is to administer multiple test measures across an extended period of time.

The following links may be helpful:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978784/

http://home.comcast.net/~staticnrg/Cushing's/LimitationsSC_UFC_dex_mildCS.pdf

http://survivethejourney.blogspot.com/2008/08/when-gold-standard-becomes-tarnished.html