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Treatments List of Categories
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Please
tell me about treatments for a Growth Hormone Deficiency.
Please
tell me about treatments for a Growth Hormone Deficiency.
Once a physician has proven GH deficiency, he or
she will begin the patient on a small dose of GH
and slowly raise the dose until a final
maintenance dose is reached. The hormone is
given daily by injection. The hormone is given
by the patient or a member of the family. Small
needles and syringes are used. The physician
will see the patient at four to eight week
intervals to ask how the patient is doing and to
obtain a blood test which can help determine the
correct dose. This test is the insulin-like
growth factor test ("IGF-1 test"). It is a
single blood test which reflects the amount of
GH administered, although it is not GH itself.
IGF-1 values which are low prompt a larger dose
or growth hormone is needed; values which are
too high prompt a lower dose. Once a final dose
is established, the blood test and office visits
will continue approximately every 4 to 6 months.
The symptoms of GH excess include muscle or
joint pain, retention of fluid (called edema)
and carpal tunnel, which consists of pain and/or
numbness in the hands. These symptoms, if
severe, will also help determine the dose.
There are other ways the physician will
monitor GH therapy. If the patient has a
pituitary tumor, an MRI will be performed before
therapy begins and usually every year
thereafter. It is not known whether or not GH
can stimulate the growth of residual tumors. The
endocrinologist physician will decide when and
how often this should be performed. The
physician will often elect to monitor blood
cholesterol and bone density. Successful therapy
is associated with an increase in the density of
bones and an improvement in blood cholesterol
profile.
From
GH Deficiency
This information was developed by David Cook,
M.D. It is not intended to substitute for a full
and frank consultation with qualified medical
personnel, which is the primary means for a
patient to obtain care and treatment. The
information was believed to be current on
November 5, 1998 and with the lapse of time,
certain of this material will be outdated.
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What is
the role of medical treatment for a growth hormone producing tumor (Acromegaly)?
Medical treatment is usually given if there is
persistent overproduction of growth hormone
after surgery. Although medications can lower
growth hormone, they are less effective in
shrinking the tumor. Therefore, the usual first
treatment is surgical removal of as much of the
tumor as is possible. In the situation of a
large tumor, particularly if it has grown into
an area that is not accessible to the surgeon,
the majority of the tumor may be removed, but a
small portion remains - and continues to produce
too much growth hormone. Because of the long
term complications of excessive growth hormone
(joint problems, diabetes, high blood pressure,
facial changes, sweating, risk of colon polyps
and colon cancer, and premature heart disease
and death), it is important to reduce growth
hormone levels to normal. In most cases,
radiation therapy is given if surgery is not
completely successful. Since it may take months
or a few years before the radiation therapy is
effective, medical treatment is used to control
excessive growth hormone production while
waiting for the radiation to become effective.
Medications do not cure the problem, they
control the situation. They are effective only
as long as they are taken as prescribed.
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What kind
of treatment is available for Turner's Syndrome?
Europe Approves Zomacton,
Human Growth Factor, For Turners Syndrome
ISELIN, NJ -- January 9, 2001 --
Bio-Technology General Corp. announced that The
Ferring Group, BTG's licensee for Europe, has
received approval from the European regulatory
authorities for BTG's recombinant human growth
hormone, in the treatment of Turner's syndrome.
The product is currently marketed by Ferring
under the tradename Zomacton in over twenty
European countries for the treatment of
pituitary growth hormone deficiency in children.
Europe constitutes approximately 30 percent of
the worldwide market for human growth hormone.
Turner's syndrome is a genetic disorder in
girls that occurs in approximately 1 in 2,500
live births and results in short stature and
failure to develop secondary sexual
characteristics. Human growth hormone is
effective in promoting growth and improving
final height in girls with this condition.
Sim Fass, Chairman and CEO of Bio-Technology
General Corp., stated: "We are pleased to now be
able to offer individuals with Turner's syndrome
an alternative to other therapies. We believe
that this additional indication will provide
Ferring with a new opportunity to further
penetrate and increase its share of the European
growth hormone market."
From http://www.pslgroup.com/dg/1ef092.htm
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